For a lot of great players, these musical concepts might not be understood on a technical level. Understanding how music works is not necessary to be able to play well. However, these ideas can serve the aspiring guitarist as a blue print of how to build a raft to get you to "cross over" to playing in a more intuitive and musical way. When you learn how music works, this understanding gives you a structure of what is important to focus on - it helps to narrow down the things that are important to explore with your hands and ears.
I choose the key of C# because there is an awesome version of “The Thrill is Gone” at the Crossroads festival in 2010 with a group of famous players. After watching this video lesson, you will have a better context to understand each player’s unique approach, as well as some tools to start developing your own style.